Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core-Reference-Cited by-同舟云学术

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Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core

Published:2021-01 Issue: Volume:210 Page:112959
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Zhang Qiuyue^ORCID,Wu Xuexuan,Zhou Jianrui,Zhang Lixiao,Xu Xiaoli,Zhang Lianshan,You Qidong^ORCID,Wang Lei^ORCID

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

China Pharmaceutical University

National Science & Technology

Key New Drug Creation and Manufacturing Program

State Key Laboratory of Natural Medicines

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference39 articles.

1. HSP90 and the chaperoning of cancer;Whitesell;Nat. Rev. Canc.,2005

2. HSP90 at the hub of protein homeostasis: emerging mechanistic insights;Taipale;Nat. Rev. Mol. Cell Biol.,2010

3. Structure, function, and regulation of the Hsp90 machinery;Biebl;Cold Spring Harb. Perspect. Biol.,2019

4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition;Taipale;Cell,2012

5. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4;Stepanova;Genes Dev.,1996

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeting HSP90 for Cancer Therapy: Current Progress and Emerging Prospects;Journal of Medicinal Chemistry;2024-09-10

2. Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies;Journal of Hematology & Oncology;2024-09-04

3. The anticancer therapeutic potential of pyrimidine–sulfonamide hybrids;Future Medicinal Chemistry;2024-04-16

4. Rational Design of Peptide Inhibitors Targeting HSP90–CDC37 Protein–Protein Interaction;Future Medicinal Chemistry;2024-01

5. Probing the functional hotspots inside protein hydrophobic pockets by in situ photochemical trifluoromethylation and mass spectrometry;Chemical Science;2024

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