Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation
Author:
Funder
National Natural Science Foundation of China
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference41 articles.
1. The role of hypoxia-inducible factors in metabolic diseases;Gonzalez;Nat. Rev. Endocrinol.,2018
2. Hypoxia-inducible factor as an angiogenic master switch;Hashimoto;Front. Pediatr.,2015
3. Hypoxia-inducible factor 2-dependent pathways driving von hippel-lindau-deficient renal cancer;Melendez-Rodriguez;Front. Oncol.,2018
4. development, Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells;Tian;Genes Dev.,1997
5. Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor;Erbel;Proc. Natl. Acad. Sci. U. S. A.,2003
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