Repositioning of the antipsychotic trifluoperazine: Synthesis, biological evaluation and in silico study of trifluoperazine analogs as anti-glioblastoma agents-Reference-Cited by-同舟云学术

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Repositioning of the antipsychotic trifluoperazine: Synthesis, biological evaluation and in silico study of trifluoperazine analogs as anti-glioblastoma agents

Published:2018-05 Issue: Volume:151 Page:186-198
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Kang Seokmin,Lee Jung Moo,Jeon Borami,Elkamhawy Ahmed,Paik Sora,Hong Jinpyo,Oh Soo-Jin,Paek Sun Ha,Lee C. Justin,Hassan Ahmed H.E.,Kang Sang Soo,Roh Eun Joo^ORCID

Funder

KIST Institutional programs

National Research Council of Science & Technology

MEST

Korean National Research Foundation

KIST Graduate School of Science and Technology program

KIST Institutional Grant

Ministry of Health & Welfare

Ministry of Trade, Industry & Energy

the Korean government (MSIP)

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference27 articles.

1. Chemotherapy resistance of glioblastoma stem cells;Eramo;Cell Death Differ.,2006

2. Isolation of cancer stem cells from adult glioblastoma multiforme;Yuan;Oncogene,2004

3. Hallmarks of glioblastoma: a systematic review;Nørøxe;ESMO Open,2017

4. Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival;Kang;Canc. Res.,2010

5. Trifluoperazine, a well-known antipsychotic, inhibits glioblastoma invasion by binding to calmodulin and disinhibiting calcium release channel IP3R;Kang;Mol. Canc. Ther.,2017

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