2,4,5-Trisubstituted thiazole derivatives as HIV-1 NNRTIs effective on both wild-type and mutant HIV-1 reverse transcriptase: Optimization of the substitution of positions 4 and 5

Author:

Xu Zhongliang,Guo Jiamei,Yang Ying,Zhang Mengdi,Ba Mingyu,Li Zhenzhong,Cao Yingli,He Ricai,Yu Miao,Zhou Hua,Li Xiaoxi,Huang Xiaoshan,Guo Ying,Guo Changbin

Funder

National Natural Basic Research Program of China

R & D

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference23 articles.

1. Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome;Barbaro;Curr. Pharm. Des.,2005

2. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection;Ho;Nature,1995

3. A Trial Comparing Nucleoside, Monotherapy with combination therapy in HIV-infected adults with CD4 cell Counts from 200 to 500 per cubic millimeter. AIDS Clinical Trials Group Study 175;Hammer;N. Engl. J. Med.,1996

4. Six-year follow-up of HIV-1-infected adults in a clinical trial of antiretroviral therapy with Indinavir, zidovudine, and Lamivudine, AIDS;Gulick,2003

5. Retroviral reverse transcriptase: synthesis, structure, and function;Goff;J. Acq. Immun. Def. Synd.,1990

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