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Optimization and biological evaluation of aminopyrimidine-based IκB kinase β inhibitors with potent anti-inflammatory effects

  • Published:2016-11 Issue: Volume:123 Page:544-556
  • ISSN:0223-5234
  • Container-title:European Journal of Medicinal Chemistry
  • language:en
  • Short-container-title:European Journal of Medicinal Chemistry

Author:

Shin Yongje,Lim Sang Min,Yan Hong Hua,Jung Sungwoo,Fang Zhenghuan,Jung Kyung Hee,Hong Soon-Sun,Hong Sungwoo

Funder

Institute for Basic Science

gs2:National Research Foundation of Korea

Korea Health Technology R&D Project, Ministry of Health and Welfare, Korea

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference26 articles.

1. NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review);Zhang;Int. J. Oncol.,2006

2. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs;Nakanishi;Nat. Rev. Cancer,2005

3. Integrating cell-signalling pathways with NF-kappaB and IKK function;Perkins;Nat. Rev. Mol. Cell Biol.,2007

4. A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity;Ziegelbauer;Br. J. Pharmacol.,2005

5. NF-kappaB: a key role in inflammatory diseases;Tak;J. Clin. Invest.,2001

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