C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays-Reference-Cited by-同舟云学术

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

Published:2019-09 Issue: Volume:177 Page:316-337
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Le Bihan Yann-Vaï,Lanigan Rachel M.,Atrash Butrus,McLaughlin Mark G.,Velupillai Srikannathasan,Malcolm Andrew G.,England Katherine S.,Ruda Gian Filippo,Mok N. Yi,Tumber Anthony,Tomlin Kathy,Saville Harry,Shehu Erald,McAndrew Craig,Carmichael LeAnne,Bennett James M.,Jeganathan Fiona,Eve Paul,Donovan Adam,Hayes Angela,Wood Francesca,Raynaud Florence I.,Fedorov Oleg,Brennan Paul E.^ORCID,Burke Rosemary,van Montfort Rob L.M.,Rossanese Olivia W.,Blagg Julian,Bavetsias Vassilios

Funder

Cancer Research UK

Avon Foundation for Women

SGC is a registered charity

AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation

Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative

Ministry of Economic Development and Innovation, Pfizer, São Paulo Research Foundation-FAPESP

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference57 articles.

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4. Histone demethylation by a family of JmjC Domain-containing proteins;Tsukada;Nature,2006

5. The discovery of histone demethylases;Shi;Cold Spring Harb Perspect Biol,2013

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