Enzymatic and solid-phase synthesis of new donepezil-based L- and d -glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia

Author:

Monjas Leticia,Arce Mariana P.,León Rafael,Egea Javier,Pérez Concepción,Villarroya Mercedes,López Manuela G.,Gil Carmen,Conde Santiago,Rodríguez-Franco María IsabelORCID

Funder

Spanish Ministry of Economy and Competitiveness

Consejo Superior de Investigaciones Científicas

Instituto de Salud Carlos III

European Commission - Marie Curie Actions FP7

Bayer AG

Fundación FIPSE

Spanish Ministry of Education

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference53 articles.

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2. Progress in drug development for Alzheimer's disease: an overview in relation to mitochondrial energy metabolism;Hroudová;Eur. J. Med. Chem.,2016

3. Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection;Singh;Eur. J. Med. Chem.,2013

4. Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes;Silva;Ageing Res. Rev.,2014

5. Recent advances in neurogenic small molecules as innovative treatments for neurodegenerative diseases;Herrera-Arozamena;Molecules,2016

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