Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2)

Author:

Hussein Buthaina,Ikhmais Balqis,Kadirvel Manikandan,Magwaza Rachael N.,Halbert Gavin,Bryce Richard A.,Stratford Ian J.,Freeman SallyORCID

Funder

Al-Zaytoonah University of Jordan

NRF

Aspen Pharmacare

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference40 articles.

1. Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity;Long;J. Biol. Chem.,2002

2. Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-Dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis;Iskander;Cancer Res.,2004

3. NRH:quinone oxidoreductase 2-deficient mice are highly susceptible to radiation-induced B-cell lymphomas;Iskander;Clin. Cancer Res.,2009

4. Antiproliferative effects of resveratrol and the mediating role of resveratrol targeting protein NQO2 in androgen receptor-positive, hormone-non-responsive CWR22Rv1 cells;Hsieh;Anticancer Res.,2009

5. Increased hippocampal quinone reductase 2 in Alzheimer's disease;Hashimoto;Neurosci. Lett.,2011

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