Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases

Author:

Zhang Xiangna,Xu Ana,Lv Jiahui,Zhang Qiuqiong,Ran Yingying,Wei Chao,Wu Jingde

Funder

Natural Science Foundation of Shandong Province

Key research and development plan of Shandong Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference143 articles.

1. Inflammasomes: mechanism of action, role in disease, and therapeutics;Guo;Nat. Med.,2015

2. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor;Pablo;EMBO J.,2014

3. Gout-associated uric acid crystals activate the NALP3 inflammasome;Martinon;Nature,2006

4. HMGB1 and RAGE in inflammation and cancer;Sims;Annu. Rev. Immunol.,2009

5. The NALP3 inflammasome is involved in the innate immune response to amyloid-[beta];Halle;Nat. Immunol.,2008

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