Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones-Reference-Cited by-同舟云学术

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

Published:2013-12 Issue: Volume:70 Page:758-767
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Deng Xianming,Elkins Jonathan M.,Zhang Jinwei,Yang Qingkai,Erazo Tatiana,Gomez Nestor,Choi Hwan Geun,Wang Jinhua,Dzamko Nicolas,Lee Jiing-Dwan,Sim Taebo,Kim NamDoo,Alessi Dario R.,Lizcano Jose M.,Knapp Stefan,Gray Nathanael S.

Funder

NIH

Medical Research Council

Michael J Fox foundation

AstraZeneca, Boehringer-Ingelheim

GlaxoSmithKline

Merck KgaA

Pfizer

University of California

Spanish Ministerio de Educación

Canadian Institutes for Health Research

Canada Foundation for Innovation

Genome Canada

Eli Lilly

Takeda

AbbVie

Novartis Research Foundation

Ontario Ministry of Research

Innovation and the Wellcome Trust

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference35 articles.

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4. Stat3 upregulates MEK5 expression in human breast cancer cells;Song;Oncogene,2004

5. MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion;Mehta;Oncogene,2003

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