Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists

Author:

Kim Jina,Chin Jungwook,Im Chun Young,Yoo Eun Kyung,Woo Seoyeon,Hwang Hee Jong,Cho Joong-heui,Seo Kyung-ah,Song Jaeyoung,Hwang Hayoung,Kim Kyung-Hee,Kim Nam Doo,Yoon Suk Kyoon,Jeon Jae-Han,Yoon Seung-Yun,Jeon Yong Hyun,Choi Hueng-Sik,Lee In-Kyu,Kim Seong Heon,Cho Sung JinORCID

Funder

Korea Health Industry Development Institute

Ministry of Health & Welfare, Republic of Korea

National Creative Research Initiatives

National Research Foundation of Korea

Korean government

Bio & Medical Technology Development Program of the NRF

Korean government, MSIP

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference29 articles.

1. 1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptor alpha;Xu;J. Med. Chem.,2013

2. Identification of pyrido[1,2-alpha]pyrimidine-4-ones as new molecules improving the transcriptional functions of estrogen-related receptor alpha;Peng;J. Med. Chem.,2011

3. The NR3B subgroup: an over review;Tremblay;Nucl. Recept. Signal.,2007

4. Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult;Heard;Mol. Endocrinol.,2000

5. Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease;Deblois;Biochim. Biophys. Acta,2011

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