Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase

Author:

Arias D.G.,Herrera F.E.,Garay A.S.,Rodrigues D.,Forastieri P.S.,Luna L.E.,Bürgi M.D.L.M.,Prieto C.,Iglesias A.A.,Cravero R.M.,Guerrero S.A.

Funder

UNL

CONICET

ANPCyT

UNR

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference46 articles.

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2. A second class of peroxidases linked to the trypanothione metabolism;Hillebrand;J. Biol. Chem.,2003

3. Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma brucei;Schlecker;J. Biol. Chem.,2005

4. Hydroperoxide metabolism in mammalian organs;Chance;Physiol. Rev.,1979

5. Glutathione peroxidase, glutathione reductase and glutathione transferase activities in the human artery, vein and heart;Mezzetti;J. Mol. Cell Cardiol.,1990

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