Synthesis and evaluation of 18F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression

Author:

Daumar Pierre,Zeglis Brian M.,Ramos Nicholas,Divilov Vadim,Sevak Kuntal Kumar,Pillarsetty NagaVaraKishoreORCID,Lewis Jason S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference27 articles.

1. DNA topoisomerase II and its growing repertoire of biological functions;Nitiss;Nat. Rev. Cancer,2009

2. Cellular roles of DNA topoisomerases: a molecular perspective, nature reviews;Wang;Mol. Cell. Biol.,2002

3. The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing;Deweese;Nucleic Acids Res.,2009

4. DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy;Chikamori;Curr. Cancer Drug Targets,2010

5. Quantitative analysis of topoisomerase II alpha and evaluation of its effects on cell proliferation and apoptosis in glioblastoma cancer stem cells;Hong;Neurosci. Lett.,2012

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