Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents

Author:

Chen Tsung-ChihORCID,Wu Chia-Lun,Lee Chia-Chung,Chen Chun-Liang,Yu Dah-Shyong,Huang Hsu-Shan

Funder

National Cancer Institute

National Institutes of Health

National Science Council Grants of Taiwan

Ministry of Science and Technology Grants of Taiwan

Chi-Mei Medical Center

National Defense Medical Center

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference49 articles.

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4. Topoisomerase II DNA cleavage stimulation, DNA binding activity, cytotoxicity, and physico-chemical properties of 2-aza- and 2-aza-oxide-anthracenedione derivatives;De Isabella;Mol. Pharmacol.,1995

5. Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent;Evison;Nucleic Acids Res.,2007

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