Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer
Author:
Funder
China Pharmaceutical University
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference13 articles.
1. Pancreatic cancer: yesterday, today and tomorrow;Ansari;Future Oncol.,2016
2. Synthetic lethality strategies: beyond BRCA1/2 mutations in pancreatic cancer;Hu;Cancer Sci.,2020
3. Discovery of potent and novel dual PARP/BRD4 inhibitors for efficient treatment of pancreatic cancer;Wang;J. Med. Chem.,2021
4. Biochemical and structural insights into doublecortin-like kinase domain 1;Patel;Structures,2016
5. Chemical biology toolkit for DCLK1 reveals connection to RNA processing;Liu;Cell Chem. Biol.,2020
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1. DCLK1 and its oncogenic functions: A promising therapeutic target for cancers;Life Sciences;2024-01
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