Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N′-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction-Reference-Cited by-同舟云学术

Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N′-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction

Published:2023-04 Issue: Volume:252 Page:115302
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Abed Dhulfiqar.Ali^ORCID,Ali Ahmed R.^ORCID,Lee Sumi^ORCID,Nguyen Mai-Uyen^ORCID,Verzi Michael P.^ORCID,Hu Longqin^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference44 articles.

1. Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents;Abed;Acta Pharm. Sin. B.,2015

2. Small molecule modulators of Keap1‐Nrf2‐ARE pathway as potential preventive and therapeutic agents;Magesh;Med. Res. Rev.,2012

3. Oxidants, oxidative stress and the biology of ageing;Finkel;Nature,2000

4. Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species;He;Cell. Physiol. Biochem.,2017

5. Oxidative stress;Sies;Annu. Rev. Biochem.,2017

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1. Structural modification of C2-substituents on 1,4-bis(arylsulfonamido)benzene or naphthalene-N,N′-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction;European Journal of Medicinal Chemistry;2024-02

2. Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP/PS1 Double Transgenic AD Mice by Regulating Keap1/Nrf2/HO‐1 Pathway to Improve Cognitive Impairment;Behavioural Neurology;2024-01

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