Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII-Reference-Cited by-同舟云学术

Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII

Published:2018-02 Issue: Volume:146 Page:47-59
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Bonardi Alessandro,Falsini Matteo,Catarzi Daniela^ORCID,Varano Flavia^ORCID,Di Cesare Mannelli Lorenzo,Tenci Barbara,Ghelardini Carla,Angeli Andrea,Supuran Claudiu T.,Colotta Vittoria^ORCID

Funder

University of Florida

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference35 articles.

1. Interfering with pH regulation in tumors as a therapeutic strategy;Neri;Nat. Rev. Drug Discov.,2011

2. How many carbonic anhydrase inhibition mechanisms exist?;Supuran;J. Enzym. Inhib. Med. Chem.,2016

3. Carbonic anhydrase inhibition and the management of hypoxic tumors;Supuran;Metabolites,2017

4. Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors;Sedlakova;Front. Physiol.,2014

5. Evaluation of CA IX and CA XII expression in breast cancer at varied O2 levels: CA IX is the superior surrogate imaging biomarker of tumor hypoxia;Tafreshi;Mol. Imag. Biol.,2016

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