Genome-wide hypomethylation of LINE-1 and Alu retroelements in cell-free DNA of blood is an epigenetic biomarker of human aging

Author:

Erichsen LarsORCID,Beermann Agnes,Arauzo-Bravo Marcos J.,Hassan Mohamed,Dkhil Mohamed A.,Al-Quraishy Saleh,Hafiz Taghreed A.,Fischer Johannes C.,Santourlidis Simeon

Funder

Stiftung für Altersforschung

Heinrich-Heine-Universität Düsseldorf

Diputación Foral de Gipuzkoa

Ministry of Economy and Competitiveness

MINECO

Ikerbasque, Basque Foundation for Science

Publisher

Elsevier BV

Subject

General Agricultural and Biological Sciences

Reference33 articles.

1. Decline in genomic DNA methylation through aging in a cohort of elderly subjects;Bollati;Mech. Ageing Dev.,2009

2. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L;Bourchis;Nature,2004

3. Characterization of the cell-free DNA released by cultured cancer cells;Bronkhorst;BBA,2016

4. The association of LINE-1 hypomethylation with age and centromere positive micronuclei in human lymphocytes;Cho;PLoS One,2015

5. Alu repeats and human disease;Deininger;Mol. Genet. Metab.,1999

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