Induction of drug metabolizing enzymes: A survey of in vitro methodologies and interpretations used in the pharmaceutical industry—Do they comply with FDA recommendations?

Author:

Hewitt Nicola J.,de Kanter Ruben,LeCluyse Edward

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference74 articles.

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3. Pharmaceutical research and manufacturers of america drug metabolism/clinical pharmacology technical working groups. The conduct of in vitro and in vivo drug–drug interaction studies: a PhRMA perspective;Bjornsson;J. Clin. Pharmacol.,2003

4. S.-M. Huang, Drug interaction studies—study design, data analysis, and implications for dosing and labelling. Preliminary concept paper. October 2004, http://www.fda.gov/ohrms/dockets/ac/04/briefing/2004-4079b1.htm.

5. Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague–Dawley rat, minipig, and beagle dog;Lu;Chem. Biol. Interact.,2001

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