Renal tubular and adrenal medullary tumors in the 2-year rat study with canagliflozin confirmed to be secondary to carbohydrate (glucose) malabsorption in the 15-month mechanistic rat study-Reference-Cited by-同舟云学术

Renal tubular and adrenal medullary tumors in the 2-year rat study with canagliflozin confirmed to be secondary to carbohydrate (glucose) malabsorption in the 15-month mechanistic rat study

Published:2017-11 Issue: Volume:277 Page:85-90
ISSN:0009-2797
Container-title:Chemico-Biological Interactions
language:en
Short-container-title:Chemico-Biological Interactions

Author:

De Jonghe Sandra,Johnson Mark D.,Mamidi Rao N.V.S.,Vinken Petra,Feyen Bianca,Lammens Godelieve,Proctor Jim^ORCID

Funder

Janssen Research and Development, LLC

Janssen Research & Development, a Division of Janssen Pharmaceutica NV

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference13 articles.

1. Carcinogenicity in rats of the SGLT2 inhibitor canagliflozin;De Jonghe;Chem. Biol. Interact.,2014

2. Chemically induced pheochromocytomas in rats: mechanisms and relevance for human risk assessment;Greim;Crit. Rev. Toxicol.,2009

3. Precose® [package Insert],2012

4. Carbohydrate malabsorption mechanism for tumor formation in rats treated with SGLT2 inhibitor canagliflozin;Mamidi;Chem. Biol. Interact.,2014

5. Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension;Barone;J. Biol. Chem.,2009

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3. SGLT2i: beyond the glucose-lowering effect;Cardiovascular Diabetology;2020-06-26

4. Dysplastic urothelial changes accompany empagliflozin administration in urinary bladder of experimental diabetes;International Journal of Experimental Pathology;2019-10