N-acetylcysteine prevents the geldanamycin cytotoxicity by forming geldanamycin–N-acetylcysteine adduct

Author:

Mlejnek Petr,Dolezel Petr

Funder

Univerzita Palackého v Olomouci

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference28 articles.

1. Geldanamycin a new antibiotic;DeBoer;J. Antibiot.,1970

2. Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus;Uehara;Mol. Cell. Biol.,1986

3. Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells;Whitesell;Mol. Endocrinol.,1996

4. The Ah receptor is a sensitive target of geldanamycin-induced protein turnover;Chen;Arch. Biochem. Biophys.,1997

5. The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210 bcr-abl and v-src proteins before their degradation by the proteasome;An;Cell Growth Differ.,2000

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