The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance

Author:

Moreb Jan S.,Ucar Deniz,Han Shuhong,Amory John K.,Goldstein Alex S.,Ostmark Blanca,Chang Lung-Ji

Funder

NIH U01 Grant

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference49 articles.

1. Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism;Vasiliou;Drug Metab. Rev.,2004

2. Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact;Sladek;J. Biochem. Mol. Toxicol.,2003

3. Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping;Vasiliou;Pharmacogenetics,1999

4. Aldehyde dehydrogenase gene superfamily. The 1998 update;Ziegler;Adv. Exp. Med. Biol.,1999

5. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease;Vasiliou;Pharmacology,2000

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