Delivery of the α-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules

Author:

Adams G.P,Shaller C.C,Chappell L.L,Wu C,Horak E.M,Simmons H.H,Litwin S,Marks J.D,Weiner L.M,Brechbiel M.W

Publisher

Elsevier BV

Subject

Cancer Research,Radiology Nuclear Medicine and imaging,Molecular Medicine

Reference38 articles.

1. Effect of mass of 111In-benzyl-EDTA monoclonal antibody on hepatic uptake and processing in mice;Adams;Cancer Res,1989

2. Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv;Adams;Cancer Res,1993

3. Increased affinity leads to improved selective tumor delivery of single chain Fv antibodies;Adams;Cancer Res,1998

4. Prolonged in vivo tumor retention of a human diabody targeting the extracellular domain of human HER2/neu;Adams;Brit. J. Cancer,1998

5. Monoclonal antibodies in cancer treatment;Alpaugh;BioDrugs,1999

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