A case of SCN8A-related developmental epileptic encephalopathy diagnosed by clinical speculation driven targeted DNA sequencing and remission of epilepsy by sodium channel blockers combination therapy

Author:

Mitsui Yoshitaka,Sato Hitoshi,Togi Sumihito,Ura Hiroki,Niida Yo

Funder

Kanazawa Medical University

Publisher

Elsevier BV

Reference14 articles.

1. Hammer MF, Xia M, Schreiber JM. SCN8A-Related Epilepsy and/or Neurodevelopmental Disorders. 2016 [updated 2023 Apr 6]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023.

2. Hack JB, Horning K, Juroske Short DM, Schreiber JM, Watkins JC, Hammer MF. Distinguishing Loss-of-Function and Gain-of-Function. Neurol Genet . 2023;9:e200060.

3. SCN8A epilepsy, developmental encephalopathy, and related disorders;Talwar;Pediatr Neurol,2021

4. Generalized tonic seizures with autonomic signs are the hallmark of SCN8A developmental and epileptic encephalopathy;Trivisano;Epilepsy Behav,2019

5. Recent advances in treatment of epilepsy-related sodium channelopathies;Musto;Eur J Paediatr Neurol,2020

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