CBS-H2S axis preserves the intestinal barrier function by inhibiting COX-2 through sulfhydrating human antigen R in colitis

Author:

Guo Shihao,Huang Zhihao,Zhu Jing,Yue Taohua,Wang Xin,Pan Yisheng,Bu Dingfang,Liu Yucun,Wang Pengyuan,Chen Shanwen

Funder

National Natural Science Foundation of China

National Major Science and Technology Projects of China

Publisher

Elsevier BV

Subject

Multidisciplinary

Reference40 articles.

1. Leaky gut: mechanisms, measurement and clinical implications in humans;Camilleri;Gut,2019

2. Restoring Mucosal Barrier Function and Modifying Macrophage Phenotype with an Extracellular Matrix Hydrogel: Potential Therapy for Ulcerative Colitis;Keane;J Crohns Colitis,2017

3. Impaired intestinal permeability contributes to ongoing bowel symptoms in patients with inflammatory bowel disease and mucosal healing;Chang;Gastroenterology,2017

4. Hydrogen sulfide: An endogenous regulator of the immune system;Dilek;Pharmacol Res,2020

5. Decreased Expression of Cystathionine β-Synthase Exacerbates Intestinal Barrier Injury in Ulcerative Colitis;Chen;J Crohns Colitis,2019

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