Involvement of dileucine motifs in the internalization and degradation of the insulin receptor
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference59 articles.
1. Tyrosine Phosphorylation of the Insulin Receptor During Insulin-stimulated Internalization in Rat Hepatoma Cells
2. Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region.
3. The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.
4. Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action.
5. Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail.
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