PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference39 articles.
1. The coagulation cascade: initiation, maintenance, and regulation
2. Molecular basis of vitamin K-dependent gamma-carboxylation
3. Defective propeptide processing of blood clotting factor IX caused by mutation of arginine to glutamine at position −4
4. Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor.
5. Factor IX Kawachinagano: impaired function of the Gla-domain caused by attached propeptide region due to substitution of arginine by glutamine at position −4
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