Reversible binding of platelet-derived growth factor-AA, -AB, and -BB isoforms to a similar site on the “slow” and “fast” conformations of alpha 2-macroglobulin.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference54 articles.
1. Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner
2. Possible positive autocrine feedback in the prereplicative phase of human fibroblasts
3. Cultured endothelial cells produce a platelet-derived growth factor-like protein
4. Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity
5. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF
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