The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives.-Reference-Cited by-同舟云学术

The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives.

Published:1992-12 Issue:36 Volume:267 Page:26104-26109
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Rezaie A.R.,Esmon C.T.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference37 articles.

1. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

2. The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation.

3. The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity.

4. Structure and function of thrombomodulin: a natural anticoagulant

5. The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

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