Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference39 articles.
1. DNA damage-inducible transcripts in mammalian cells.
2. Isolation and characterization of the hamster gadd153 gene. Activation of promoter activity by agents that damage DNA.
3. Cell growth inhibition by prostaglandin A2 results in elevated expression of gadd153 mRNA
4. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.
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