Evidence for an alternative pathway for colchicine binding to tubulin, based on the binding kinetics of the constituent rings.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference24 articles.
1. Interaction of tubulin with single ring analogs of colchicine
2. Conformational states of tubulin liganded to colchicine, tropolone methyl ether, and podophyllotoxin
3. Mechanism of colchicine binding to tubulin. Tolerance of substituents in ring C' of biphenyl analogs
4. Binding to tubulin of the colchicine analog 2-methoxy-5-(2', 3', 4'-trimethoxyphenyl)tropone. Thermodynamic and kinetic aspects.
5. Interactions of colchicine with tubulin
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1. The Metabolism and Biochemical Actions of Alkaloids in Animals;Bioactive Natural Products (Part C);2000
2. Phosphate Release during Microtubule Assembly: What Stabilizes Growing Microtubules?;Biochemistry;1999-06-01
3. Quantitative Characterization of the Binding of Fluorescently Labeled Colchicine to Tubulin in Vitro Using Fluorescence Correlation Spectroscopy;Biochemistry;1999-03-31
4. Separation of Tubulin Subunits under Nondenaturing Conditions;Biochemistry;1998-05-27
5. The Mechanism of Tubulin-Colchicine Recognition. A Kinetic Study of the Binding of a Bicyclic Colchicine Analogue with a Minor Modification of the A Ring;European Journal of Biochemistry;1997-10
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