The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference20 articles.
1. Changes in32P-Content of Phosphatidic Acid and the Phosphoinositides of Rabbit Platelets during Aggregation Induced by Collagen or Thrombin
2. Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products.
3. Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets
4. Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin
5. Phosphatidylinositol-specific phospholipase-C of platelets: Association with 1,2-diacylglycerol-kinase and inhibition by cyclic-AMP
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