Bifunctional thrombin inhibitors based on the sequence of hirudin45-65.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference34 articles.
1. INHIBITION OF THROMBIN AND TRYPSIN BY TRIPEPTIDE ALDEHYDES
2. The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
3. Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin
4. The functional domain of hirudin, a thrombin-specific inhibitor
5. Point mutations modifying the thrombin inhibition kinetics and antithrombotic activity in vivo of recombinant hirudin
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