An oncogenic point mutation confers high affinity ligand binding to the neu receptor. Implications for the generation of site heterogeneity.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference56 articles.
1. Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.
2. Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion.
3. The neu oncogene encodes an epidermal growth factor receptor-related protein
4. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185
5. High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.
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