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Cytosolic phospholipase A2α sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells

  • Published:2013-06 Issue:6 Volume:1831 Page:1146-1157
  • ISSN:1388-1981
  • Container-title:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • language:en
  • Short-container-title:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Author:

Hua Sheng,Yao Mu,Vignarajan Soma,Witting Paul,Hejazi Leila,Gong Zhen,Teng Ying,Niknami Marzieh,Assinder Stephen,Richardson Des,Dong Qihan

Funder

Sydney Medical School Foundation

Australian Research Council

National Health & Medical Research Council (NHMRC)

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference61 articles.

1. Synthesis and function of 3-phosphorylated inositol lipids;Vanhaesebroeck;Annu. Rev. Biochem.,2001

2. PTEN and the PI3-kinase pathway in cancer;Chalhoub;Annu. Rev. Pathol.,2009

3. Activation of AKT kinases in cancer: implications for therapeutic targeting;Bellacosa;Adv. Cancer Res.,2005

4. Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer;Malik;Clin. Cancer Res.,2002

5. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells;Sun;Am. J. Pathol.,2001
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