Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL
Author:
Funder
National Eye Institute Intramural Research Program
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology
Reference33 articles.
1. Cholesterol oxidation in the retina: implications of 7-ketocholesterol formation in chronic inflammation and age-related macular degeneration;Rodriguez;J. Lipid Res.,2010
2. Oxysterols in the pathogenesis of major chronic diseases;Poli;Redox Biol.,2013
3. Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages;Brown;J. Lipid Res.,1996
4. 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation;Moreira;Invest. Ophthalmol. Vis. Sci.,2009
5. 7-Ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen;Rodriguez;Exp. Eye Res.,2014
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