Implementation of dihydropyrimidine dehydrogenase deficiency testing in Europe

Author:

de With M.,Sadlon A.,Cecchin E.,Haufroid V.,Thomas F.,Joerger M.,van Schaik R.H.N.,Mathijssen R.H.J.,Largiadèr C.R.

Funder

European Commission

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference36 articles.

1. European Medicines Agency (EMA). Summary of product characteristics (SmPC) Capecitabine Xeloda. Available at https://www.ema.europa.eu/en/documents/product-information/xeloda-epar-product-information_en.pdf. Accessed March 20, 2023.

2. Medicines Evaluation Board (MEB). Summary of product characteristics (SmPC) fluorouracil 50 mg/ml solution for injection or infusion. Available at https://www.geneesmiddeleninformatiebank.nl/smpc/h100701_smpc.pdf. Accessed March 20, 2023.

3. Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data;Meulendijks;Lancet Oncol,2015

4. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study;Hoff;J Clin Oncol,2001

5. Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial;Koopman;Lancet,2007

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