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G2019S LRRK2 mutant fibroblasts from Parkinson’s disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy

  • Published:2014-10 Issue: Volume:324 Page:1-9
  • ISSN:0300-483X
  • Container-title:Toxicology
  • language:en
  • Short-container-title:Toxicology

Author:

Yakhine-Diop Sokhna M.S.,Bravo-San Pedro José M.,Gómez-Sánchez Rubén,Pizarro-Estrella Elisa,Rodríguez-Arribas Mario,Climent Vicente,Aiastui Ana,de Munain Adolfo López,Fuentes José M.,González-Polo Rosa A.

Funder

ISCIII

Instituto Biodonostia

Ministerio de Economía y Competitividad, Spain

Ministerio de Economía y Competitividad, Spain, CIBERNED

Consejería, Economía, Comercio e Innovación, Gobierno de Extremadura

Association Francaise contre les Myopathies

Spanish Ministry of Health

Ilundain Foundation, Isabel Gemio Foundation, Diputacion Foral de Gipuzkoa

SAIOTEK

Publisher

Elsevier BV

Subject

Toxicology

Reference44 articles.

1. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model;Alegre-Abarrategui;Hum. Mol. Genet.,2009

2. Apoptosis and autophagy in nigral neurons of patients with Parkinson’s disease;Anglade;Histol. Histopathol.,1997

3. Gene–environment interactions in sporadic Parkinson’s disease;Benmoyal-Segal;J. Neurochem.,2006

4. The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts;Bravo-San Pedro;Autophagy,2012

5. The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway;Bravo-San Pedro;Cell. Mol. Life Sci.,2013
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