Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding

Author:

Borghoff S.J.,Poet T.S.,Green S.,Davis J.,Hughes B.,Mensing T.,Sarang S.S.,Lynch A.M.,Hard G.C.

Publisher

Elsevier BV

Subject

Toxicology

Reference39 articles.

1. TLVs and BEIs Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices;American Conference of Governmental Industrial Hygenists (ACGIH),2005

2. Biochemical mechanism and pathobiology of α2u-globulin nephropathy;Borghoff;Ann. Rev. Pharmacol. Toxicol.,1990

3. Characteristics of chemical binding to α2u-globulin in vitro – evaluating structure activity relationships;Borghoff;Toxicol. Appl. Pharmacol.,1991

4. α2u-Globulin nephropathy, renal cell proliferation and dosimetry of inhaled tert butyl alcohol in male and female Fischer 344 rats;Borghoff;Toxicol. Sci.,2001

5. Methyl isobutyl ketone (MIBK) induction of α2u-globulin nephropathy in male, but not female rats;Borghoff;Toxicology,2009

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