Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing-Reference-Cited by-同舟云学术

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Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing

Published:2021-07 Issue:14 Volume:184 Page:3689-3701.e22
ISSN:0092-8674
Container-title:Cell
language:en
Short-container-title:Cell

Author:

Kober Daniel L.,Radhakrishnan Arun,Goldstein Joseph L.,Brown Michael S.,Clark Lindsay D.,Bai Xiao-chen,Rosenbaum Daniel M.

Funder

NHLBI

Fondation Leducq

NIGMS

Welch Foundation

American Heart Association

Cancer Prevention and Research Institute of Texas

National Institutes of Health

Edward Mallinckrodt, Jr. Foundation

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference54 articles.

1. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs;Adams;J. Biol. Chem.,2004

2. Sampling the conformational space of the catalytic subunit of human γ-secretase;Bai;eLife,2015

3. Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase;Brown;J. Biol. Chem.,1978

4. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor;Brown;Cell,1997

5. Retrospective on Cholesterol Homeostasis: The Central Role of Scap;Brown;Annu. Rev. Biochem.,2018

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2. N-SREBP2 Provides a Mechanism for Dynamic Control of Cellular Cholesterol Homeostasis;Cells;2024-07-25

3. SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain;Nature Communications;2024-07-09

4. A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells;Proceedings of the National Academy of Sciences;2024-02-08

5. Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase;Proceedings of the National Academy of Sciences;2024-02-06

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