Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome-Reference-Cited by-同舟云学术

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Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

Published:2014-02 Issue:4 Volume:156 Page:771-785
ISSN:0092-8674
Container-title:Cell
language:en
Short-container-title:Cell

Author:

Menon Suchithra,Dibble Christian C.,Talbott George,Hoxhaj Gerta,Valvezan Alexander J.,Takahashi Hidenori,Cantley Lewis C.,Manning Brendan D.

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference51 articles.

1. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1;Bar-Peled;Cell,2012

2. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1;Bar-Peled;Science,2013

3. GEFs and GAPs: critical elements in the control of small G proteins;Bos;Cell,2007

4. Localization of Rheb to the endomembrane is critical for its signaling function;Buerger;Biochem. Biophys. Res. Commun.,2006

5. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning;Cai;J. Cell Biol.,2006

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3. mTORC1 hampers Hedgehog signaling inTsc2deficient cells;Life Science Alliance;2024-08-26

4. Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway;Proceedings of the National Academy of Sciences;2024-08-20

5. Calmodulin enhances mTORC1 signaling by preventing TSC2-Rheb binding;2024-08-20

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