Germinal centers output clonally diverse plasma cell populations expressing high- and low-affinity antibodies

Author:

Sprumont Adrien,Rodrigues Ana,McGowan Simon J.,Bannard Colin,Bannard OliverORCID

Funder

Wellcome Trust

Medical Research Council

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference70 articles.

1. Germinal centers: programmed for affinity maturation and antibody diversification;Bannard;Curr. Opin. Immunol.,2017

2. Germinal centers;Victora;Annu. Rev. Immunol.,2022

3. Expression of the plasma cell transcriptional regulator Blimp-1 by dark zone germinal center B cells during periods of proliferation;Radtke;Front. Immunol.,2018

4. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response;Smith;EMBO J.,1997

5. High affinity germinal center B cells are actively selected into the plasma cell compartment;Phan;J. Exp. Med.,2006

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