A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

Author:

El Khattabi Laila,Zhao Haiyan,Kalchschmidt Jens,Young Natalie,Jung Seolkyoung,Van Blerkom Peter,Kieffer-Kwon Philippe,Kieffer-Kwon Kyong-Rim,Park Solji,Wang Xiang,Krebs Jordan,Tripathi Subhash,Sakabe Noboru,Sobreira Débora R.,Huang Su-Chen,Rao Suhas S.P.,Pruett Nathanael,Chauss Daniel,Sadler Erica,Lopez Andrea,Nóbrega Marcelo A.,Aiden Erez Lieberman,Asturias Francisco J.,Casellas Rafael

Funder

NIH Helix Systems

NIAMS (National Institute of Arthritis and Musculoskeletal and Skin Diseases

NIGMS (National Institute of General Medical Sciences

NSF

Welch Foundation

NVIDIA Research Center Award

IBM University Challenge

Google Research

Cancer Prevention Research Institute of Texas

McNair Medical Institute

President’s Early Career Award in Science and Engineering

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference93 articles.

1. Live-Cell Imaging Reveals Enhancer-dependent Sox2 Transcription in the Absence of Enhancer Proximity;Alexander;bioRxiv,2018

2. The Mediator complex: a central integrator of transcription;Allen;Nat. Rev. Mol. Cell Biol.,2015

3. Differential expression analysis for sequence count data;Anders;Genome Biol.,2010

4. HTSeq–a Python framework to work with high-throughput sequencing data;Anders;Bioinformatics,2015

5. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis;Aranda-Orgilles;Cell Stem Cell,2016

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