A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9

Author:

Maji Basudeb,Gangopadhyay Soumyashree A.,Lee Miseon,Shi Mengchao,Wu Peng,Heler Robert,Mok Beverly,Lim Donghyun,Siriwardena Sachini U.,Paul Bishwajit,Dančík Vlado,Vetere Amedeo,Mesleh Michael F.,Marraffini Luciano A.,Liu David R.,Clemons Paul A.,Wagner Bridget K.,Choudhary Amit

Funder

National Institutes of Health

Army Research Office

Defense Sciences Office, DARPA

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference52 articles.

1. Cheating evolution: engineering gene drives to manipulate the fate of wild populations;Champer;Nat. Rev. Genet.,2016

2. Identification of pre-existing adaptive immunity to Cas9 proteins in humans;Charlesworth;bioRxiv,2018

3. The chemistry of Cas9 and its CRISPR colleagues;Chen;Nat. Rev. Chem.,2017

4. Utilizing diversity-oriented synthesis in antimicrobial drug discovery;Comer;Future Med. Chem.,2014

5. Comer, E., Munoz, B., Beaudoin, J.A., Le Quement, S.T., Scherer, C., Duvall, J., Kato, N., Maetani, M., and Braibant, B. (2015). Compounds for the treatment of malaria. WIPO patent WO2015002755, filed June 20, 2014, and granted January 8, 2015.

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