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Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons

  • Published:2015-09 Issue:6 Volume:162 Page:1404-1417
  • ISSN:0092-8674
  • Container-title:Cell
  • language:en
  • Short-container-title:Cell

Author:

Steculorum Sophie M.,Paeger Lars,Bremser Stephan,Evers Nadine,Hinze Yvonne,Idzko Marco,Kloppenburg Peter,Brüning Jens C.

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference52 articles.

1. Purinergic signalling in the nervous system: an overview;Abbracchio;Trends Neurosci.,2009

2. Strategies to discover unexpected targets for drugs active at G protein-coupled receptors;Allen;Annu. Rev. Pharmacol. Toxicol.,2011

3. Feedback Inhibition of Uridine Kinase by Cytidine Triphosphate and Uridine Triphosphate;Anderson;Biochim. Biophys. Acta,1964

4. Central mechanisms involved in the orexigenic actions of ghrelin;Andrews;Peptides,2011

5. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training;Aponte;Nat. Neurosci.,2011

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