Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Author:

Petljak Mia,Alexandrov Ludmil B.,Brammeld Jonathan S.,Price Stacey,Wedge David C.,Grossmann Sebastian,Dawson Kevin J.,Ju Young Seok,Iorio Francesco,Tubio Jose M.C.,Koh Ching Chiek,Georgakopoulos-Soares Ilias,Rodríguez–Martín Bernardo,Otlu Burçak,O’Meara Sarah,Butler Adam P.,Menzies Andrew,Bhosle Shriram G.,Raine Keiran,Jones David R.,Teague Jon W.,Beal Kathryn,Latimer Calli,O’Neill Laura,Zamora Jorge,Anderson Elizabeth,Patel Nikita,Maddison Mark,Ng Bee Ling,Graham Jennifer,Garnett Mathew J.,McDermott Ultan,Nik-Zainal Serena,Campbell Peter J.,Stratton Michael R.

Funder

Wellcome

Cancer Research UK

Li Ka Shing Foundation

National Institute for Health Research Oxford Biomedical Research Centre

Xunta de Galicia

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference74 articles.

1. Clock-like mutational processes in human somatic cells;Alexandrov;Nat. Genet.,2015

2. The Repertoire of Mutational Signatures in Human Cancer;Alexandrov;bioRxiv,2018

3. Signatures of mutational processes in human cancer;Alexandrov;Nature,2013

4. Deciphering signatures of mutational processes operative in human cancer;Alexandrov;Cell Rep.,2013

5. Statistical design and analysis of RNA sequencing data;Auer;Genetics,2010

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