The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies

Author:

Copin Richard,Baum Alina,Wloga Elzbieta,Pascal Kristen E.,Giordano Stephanie,Fulton Benjamin O.,Zhou Anbo,Negron Nicole,Lanza Kathryn,Chan Newton,Coppola Angel,Chiu Joyce,Ni Min,Wei Yi,Atwal Gurinder S.,Hernandez Annabel Romero,Saotome Kei,Zhou Yi,Franklin Matthew C.,Hooper Andrea T.,McCarthy Shane,Hamon Sara,Hamilton Jennifer D.,Staples Hilary M.,Alfson Kendra,Carrion Ricardo,Ali Shazia,Norton Thomas,Somersan-Karakaya Selin,Sivapalasingam Sumathi,Herman Gary A.,Weinreich David M.,Lipsich Leah,Stahl Neil,Murphy Andrew J.,Yancopoulos George D.,Kyratsous Christos A.

Funder

Biomedical Advanced Research and Development Authority

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference36 articles.

1. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies;Baum;Science,2020

2. REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters;Baum;Science,2020

3. SARS-CoV-2 Variant Classifications and Definitions,2021

4. Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7;Davies;medRxiv,2021

5. Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail;Dong;bioRxiv,2021

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