Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

Author:

Kang Rui,Zeng Ling,Zhu Shan,Xie Yangchun,Liu Jiao,Wen Qirong,Cao Lizhi,Xie Min,Ran Qitao,Kroemer Guido,Wang Haichao,Billiar Timothy R.,Jiang Jianxin,Tang Daolin

Funder

US NIH

Natural Science Foundation of Guangdong Province

American Cancer Society

Research Scholar Grant

National Natural Science Foundation of China

Guangdong Province Universities

Colleges Pearl River Scholar Funded Scheme

Lin He's Academician Workstation of New Medicine and Clinical Translation

International Scientific and Technology Cooperation Program of China

University of Pittsburgh Cancer Institute

Ligue contre le Cancer Comité de Charente-Maritime

Agence National de la Recherche (ANR) – Projets blancs

ANR under the frame of E-Rare-2

ERA-Net for Research on Rare Diseases

Association pour la recherche sur le cancer

Cancéropôle Île-de-France

Chancelerie des universités de Paris

Fondation pour la Recherche Médicale

European Commission

European Research Council

Fondation Carrefour

Institut National du Cancer

Inserm

Institut Universitaire de France

LeDucq Foundation

LabEx Immuno-Oncology

RHU Torino Lumière

Searave Foundation

SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination

SIRIC Cancer Research

Personalized Medicine

Paris Alliance of Cancer Research Institutes

Publisher

Elsevier BV

Subject

Virology,Microbiology,Parasitology

Reference56 articles.

1. Caspase-11 protects against bacteria that escape the vacuole;Aachoui;Science,2013

2. GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes;Aglietti;Proc. Natl. Acad. Sci. USA,2016

3. Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in BALB/c mice;Andujar;Evid. Based Complement. Alternat. Med.,2012

4. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g;Boyum;Scand. J. Clin. Lab. Invest. Suppl.,1968

5. Glutathione peroxidases;Brigelius-Flohe;Biochim. Biophys. Acta,2013

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