DHA-enriched fish oil upregulates cyclin-dependent kinase inhibitor 2A (P16INK) expression and downregulates telomerase activity without modulating effects of PPARγ Pro12Ala polymorphism in type 2 diabetic patients: A randomized, double-blind, placebo-controlled clinical trial

Author:

Toupchian Omid,Sotoudeh Gity,Mansoori Anahita,Abdollahi Shima,Ali Keshavarz Seyyed,Djalali Mahmoud,Nasli-Esfahani Ensieh,Alvandi Ehsan,Chahardoli Reza,Koohdani Fariba

Funder

Tehran University of Medical Sciences

Endocrinology and Metabolism Research Center

Iran's National Science Foundation (INSF)

Publisher

Elsevier BV

Subject

Critical Care and Intensive Care Medicine,Nutrition and Dietetics

Reference40 articles.

1. The peroxisome proliferator-activated receptor: a family of nuclear receptors role in various diseases;Tyagi;J Adv Pharm Technol Res,2011

2. PPARα inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a;Gizard;J Clin Investigation,2005

3. The PPARα/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle–dependent telomerase activation;Gizard;Circulation Res,2008

4. Activation of p53 protein by telomeric (TTAGGG) n repeats;Milyavsky;Nucleic Acids Res,2001

5. Introduction of p16INK4a inhibits telomerase activity through transcriptional suppression of human telomerase reverse transcriptase expression in human gliomas;Saito;Int J Oncol,2004

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