Enzymatic formation and chemical synthesis of an active metabolite of 3β-hydroxy-5α-cholest-8(14)-en-15-one, a potent regulator of cholesterol metabolism-Reference-Cited by-同舟云学术

Enzymatic formation and chemical synthesis of an active metabolite of 3β-hydroxy-5α-cholest-8(14)-en-15-one, a potent regulator of cholesterol metabolism

Published:1988-02 Issue:1 Volume:151 Page:130-136
ISSN:0006-291X
Container-title:Biochemical and Biophysical Research Communications
language:en
Short-container-title:Biochemical and Biophysical Research Communications

Author:

Schroepfer George J.,Kim Hong-Seok,Vermilion Janice L.,Stephens Thomas W.,Pinkerton Frederick D.,Needleman Dolores H.,Wilson William K.,Pyrek Jan St.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference32 articles.

1. Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.

2. 14 alpha-Ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol, a potent inhibitor of sterol biosynthesis, has two sites of action in cultured mammalian cells.

3. Inhibitors of sterol synthesis. Dietary administration of 5α-cholest-8(14)-en-3β-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats

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